Publications
Ten peer-reviewed papers published between 2010 and 2025, including the Nature Cell Biology and Nature Communications results that underpin the oncology and arthritis programs.
ER O-glycosylation in synovial fibroblasts drives cartilage degradation.
Nat. Commun. 16(1):2535 (2025). DOI: 10.1038/s41467-025-57401-9
Src activates retrograde membrane traffic through phosphorylation of GBF1.
eLife. 10:268678 (2021). DOI: 10.7554/eLife.68678
ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells.
Nat. Cell Biol. 22(11) 1371–1381 (2020). DOI: 10.1038/s41556-020-00590-w
The GalNAc-T Activation (GALA) Pathway: Drivers and markers.
PLoS One. 19;14(3):e0214118 (2019). DOI: 10.1371/journal.pone.0214118
Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Cancer Cell. 13;32(5):639-653.e6 (2017). DOI: 10.1016/j.ccell.2017.10.001
Short O-GalNAc glycans: regulation and role in tumor development and clinical perspectives.
Biochim Biophys Acta. 1860(8):1623-39 (2016). DOI: 10.1016/j.bbagen.2016.03.008
Cracking the glycome encoder: signaling, trafficking, and glycosylation.
Trends Cell Biol. 26, 379–388 (2016). DOI: 10.1016/j.tcb.2015.12.004
ERK8 is a negative regulator of O-GalNAc glycosylation and cell migration.
eLife 3, e01828 (2014). DOI: 10.7554/eLife.01828
Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness.
Proc. Natl Acad. Sci. USA 110, E3152–E3161 (2013). DOI: 10.1073/pnas.1305269110
Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes.
J. Cell Biol. 189(5):843-858 (2010). DOI: 10.1083/jcb.201003055